Why the study?
Does NO synthesis inhibition with L-NAME alter renal hemodynamics and blood pressure in rats with early and chronic 2K1C renovascular hypertension?
Population
Rats with two-kidney, one clip renovascular hypertension, either early-phase or chronic-phase.
Comparison
N omega-nitro-L-arginine methyl ester 10 mg/kg… vs Baseline measurements and untreated…
Design
Preclinical
Authors
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NO inhibition exacerbates hypertension and renal vasoconstriction in 2K1C rats; hypothesis-generating for human renovascular hypertension and requires clinical validation.
Does NO synthesis inhibition with L-NAME alter renal hemodynamics and blood pressure in rats with early and chronic 2K1C renovascular hypertension?
Nitric oxide provides significant dilator tone to buffer hypertension and maintain renal perfusion in both early and chronic phases of 2K1C renovascular hypertension, counterbalancing angiotensin-independent vasoconstriction.
Sigmon et al. (1998) studied this question.
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