Population
2-kidney, 1 clip (2KIC) hypertensive rats (7-week and 12-week hypertensive) and normal control rats
Comparison
NG-nitro-L-arginine-methyl ester or EDNO… vs Normal control rats
Design
Preclinical
Follow-up
7 and 12 weeks
Authors
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Progressive endothelial dysfunction in this rat model may sustain hypertension; hypothesis-generating and should not yet inform clinical practice.
Chronic 2KIC hypertension is associated with progressive endothelial dysfunction that may contribute to sustained high blood pressure, despite EDNO having little influence during the developmental phase.
Choi et al. (1994) studied this question.
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