Population
Ren-2 transgenic rats and Sprague-Dawley control rats at 6 (young) and 12 (adult) weeks of age
Comparison
Ex vivo assessment of isolated left anterior… vs Sprague-Dawley control rats
Design
Preclinical
Authors
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Hypothesis-generating for altered coronary endothelial function in hypertension; requires human validation before any clinical relevance.
Ren-2 transgenic rats with fulminant hypertension exhibit a selective decrease in endothelium-dependent contractions in coronary arteries, while endothelium-dependent relaxations remain intact.
Tschudi et al. (1994) studied this question.
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