Population
Isolated aorta of mouse Ren-2 transgenic rats (TGR(mRen2)27) and Sprague-Dawley rats (SD)
Comparison
Application of vasoactive agonists and antagonists vs Aorta from control Sprague-Dawley (SD) rats
Design
Preclinical
Authors
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Endothelial dysfunction in this Ren-2 model suggests vascular impairment in hypertension; leaves open human relevance and therapeutic implications.
In a transgenic rat model of hypertension, Ren-2 overexpression leads to marked alterations in aortic vascular function, including impaired endothelium-dependent relaxation.
Arnet et al. (1999) studied this question.
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