Why the study?
Does Angiotensin II administration elicit exaggerated renal and peripheral vascular responses in hypertensive ren-2 transgenic rats compared to control rats?
Does Angiotensin II administration elicit exaggerated renal and peripheral vascular responses in hypertensive ren-2 transgenic rats compared to control rats?
Hypertensive ren-2 transgenic rats exhibit exaggerated renal and peripheral vascular responsiveness to Angiotensin II, which likely contributes to their hypertension.
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Exaggerated ANG II responsiveness may drive hypertension in this model; extends transgenic rat studies but leaves human translation open.
Jacinto et al. (1999) studied this question.
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