Why the study?
Does intrarenal angiotensin II influence the development of hypertension in Ren-2 transgenic rats?
Population
Male anaesthetized Ren-2 transgenic rats and Hannover Sprague-Dawley rats aged 36-38 days
Comparison
Intravenous and intrarenal boluses of… vs Hannover Sprague-Dawley rats (control strain)
Design
Preclinical
Authors
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Supports enhanced intrarenal angiotensin II effects in prehypertensive Ren-2 rats; hypothesis-generating with no immediate clinical implications.
Does intrarenal angiotensin II influence the development of hypertension in Ren-2 transgenic rats?
Prehypertensive transgenic rats exhibit inappropriately high angiotensin II-dependent influence on kidney function, contributing to hypertension development.
Kopkan et al. (2005) studied this question.
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