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June 10, 2006AJP Heart and Circulatory Physiology

Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats

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Why the study?

Does lisinopril or losartan alter the ANG-(1-7)/ACE2 axis and blood pressure in Lew.Tg(mRen2) congenic hypertensive rats?

Population

Lew.Tg(mRen2) congenic hypertensive rat strain

Comparison

Lisinopril or losartan administered for 12 days vs Untreated/control (implied)

Design

Preclinical

Follow-up

12 days

Authors

JJJewell A. JessupTris Pharma (United States)PGPatricia E. GallagherWake Forest UniversityDADavid B. AverillGeisinger Commonwealth School of Medicine

Discussion

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Implication

Hypothesis-generating in hypertensive rats; leaves open whether ACEi/ARB effects on ACE2 translate to patients.

Structured PICO

Does lisinopril or losartan alter the ANG-(1-7)/ACE2 axis and blood pressure in Lew.Tg(mRen2) congenic hypertensive rats?

P
Population
Lew.Tg(mRen2) congenic hypertensive rat strain
I
Intervention
Lisinopril or losartan administered for 12 days
C
Comparator
Untreated/control (implied)
O
Outcome
Effects on the ANG-(1-7)/ACE2 axis of the renin-angiotensin system (including cardiac and renal ACE2/ACE mRNA expression, plasma and urinary ANG II and ANG-(1-7) levels) and blood pressuresurrogate

In a novel congenic hypertensive rat model, ACE inhibition and AT1 receptor blockade reduced blood pressure and upregulated cardiac and renal ACE2 expression, highlighting the complex role of the ANG-(1-7)/ACE2 axis in hypertension.

Cite This Study

Jessup et al. (2006) studied this question.

synapsesocial.com/papers/6a717e9fb5c1fe5ca9dfd9b4https://doi.org/10.1152/ajpheart.00061.2006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vasodepressor Actions of Angiotensin-(1–7) Unmasked During Combined Treatment With Lisinopril and Losartan1998 · 229 citations
  2. 2Contribution of Local Renin-Angiotensin System to Cardiac Hypertrophy, Phenotypic Modulation, and Remodeling in TGR(mRen2)27 Transgenic Rats1996 · 70 citations
  3. 3Divergent Regulation of Circulating and Intrarenal Renin-Angiotensin Systems in Response to Long-Term Blockade2005 · 24 citations
  4. 4Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 22005 · 1,618 citations
  5. 5Renal function in hypertensive rats transgenic for mouse renin gene1994 · 35 citations