April 1, 2000Hypertension

Synergistic Effects of AT₁and ETAReceptor Blockade in a Transgenic, Angiotensin II–Dependent, Rat Model

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Why the study?

Does combined AT1 and ETA receptor blockade reduce blood pressure and end-organ damage in a transgenic rat model of renin-dependent hypertension?

Structured PICO

Does combined AT1 and ETA receptor blockade reduce blood pressure and end-organ damage in a transgenic rat model of renin-dependent hypertension?

Population

Rats transgenic for both human renin and angiotensinogen genes, studied between 6 to 10 weeks of age (n=12 per group).

Intervention

Combination of subdepressor doses of losartan (10 mg/kg) and LU 135252 (30 mg/kg).

Comparator

Untreated transgenic rats, transgenic rats receiving single losartan (10 mg/kg), transgenic rats receiving single LU 135252 (30 mg/kg), and nontransgenic rats.

Outcome

Blood pressure, mortality, and end-organ damage (cardiac hypertrophy, water intake, and gene expression for atrial natriuretic peptide, collagen III, and ACE).surrogate

The combination of AT1 and ETA receptor blockade synergistically normalizes blood pressure and prevents mortality in a rat model of renin-dependent hypertension.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support clinical use; leaves open whether dual AT1/ETA blockade benefits translate beyond this rat model.

Cite This Study

Bohlender et al. (2000) studied this question.

synapsesocial.com/papers/6a8308dad1e5557f1151aaa0 https://doi.org/10.1161/01.hyp.35.4.992

Topics

Hypertension management

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Synergistic Effects of AT₁and ETAReceptor Blockade in a Transgenic, Angiotensin II–Dependent, Rat Model

Structured PICO

Discussion

Implication

Cite This Study

Topics

Synergistic Effects of AT₁and ETAReceptor Blockade in a Transgenic, Angiotensin II–Dependent, Rat Model

Structured PICO

Discussion

Implication

Cite This Study

Keep reading

Topics

Keep reading