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April 1, 2000Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Blockade of Angiotensin II Type 1 Receptor and Not of Endothelin Receptor Prevents Hypertension and Cardiovascular Disease in Transgenic (mREN2)27 Rats via Adrenocortical Steroid–Independent Mechanisms

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Why the study?

Does blockade of Angiotensin II Type 1 Receptor or Endothelin Receptor prevent hypertension and cardiovascular disease in transgenic (mREN2)27 rats?

Population

Four-week-old heterozygous male transgenic27 rats, a model of monogenic renin-dependent severe hypertension…

Comparison

Bosentan, irbesartan, or BMS-182874 for 4 weeks vs Placebo

Design

Preclinical, randomly allocated

Follow-up

4 weeks

Authors

GRGian Paolo RossiASAlfredo SacchettoDRDamiano Rizzoni

Discussion

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Overview

AT1 but not ET blockade attenuates hypertension and LV mass in this rat model; hypothesis-generating, leaves open human translation.

Structured PICO

Does blockade of Angiotensin II Type 1 Receptor or Endothelin Receptor prevent hypertension and cardiovascular disease in transgenic (mREN2)27 rats?

P
Population
Four-week-old heterozygous male transgenic (mREN2)27 rats (n=24), a model of monogenic renin-dependent severe hypertension and cardiovascular disease
I
Intervention
Bosentan (100 mg/kg BW PO), irbesartan (50 mg/kg BW PO), or BMS-182874 (52 mg/kg BW PO) for 4 weeks
C
Comparator
Placebo
O
Outcome
Systolic blood pressure, left ventricular weight, tension responses to vasoconstrictors, normalized media thickness of mesenteric arterioles, and plasma aldosterone levelssurrogate

Angiotensin II type 1 receptor blockade, but not endothelin receptor blockade, prevents hypertension and target organ damage in a renin-dependent rat model of severe hypertension.

Cite This Study

Rossi et al. (2000) studied this question.

synapsesocial.com/papers/6a815c20d7cc36764366295ehttps://doi.org/10.1161/01.atv.20.4.949
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