Why the study?
Does ET(A)-receptor antagonist ABT-627 prevent arterial pressure increases and renal hemodynamic changes in a rat model of chronic ANG II-induced hypertension?
Population
Male Sprague-Dawley rats
Comparison
Endothelin type A (ET)-receptor antagonist… vs Chronic ANG II infusion without ABT-627…
Design
Preclinical
Follow-up
2 weeks
Authors
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Does not support clinical use; leaves open endothelin mediation of ANG II hypertension in humans.
Does ET(A)-receptor antagonist ABT-627 prevent arterial pressure increases and renal hemodynamic changes in a rat model of chronic ANG II-induced hypertension?
ET(A)-receptor antagonism abolishes the hypertensive effect and attenuates the GFR decrease induced by chronic ANG II infusion in rats, suggesting the renal endothelin system mediates these actions.
Alexander et al. (2001) studied this question.
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