Why the study?
Does chronic ANG II infusion increase urinary excretion of renin, angiotensinogen, and ANG II in Sprague-Dawley rats?
Population
Sprague-Dawley rats (n=20)
Comparison
Chronic angiotensin II infusion vs Sham operation
Design
Preclinical
Follow-up
14 days
Authors
Loading...
Indicates collecting duct renin secretion in ANG II hypertension; leaves open translation to human disease mechanisms.
Does chronic ANG II infusion increase urinary excretion of renin, angiotensinogen, and ANG II in Sprague-Dawley rats?
In ANG II-dependent hypertensive rats, increased urinary levels of renin and prorenin reflect augmented secretion by collecting duct cells, facilitating intratubular ANG II formation.
Liu et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: