Key result
Chronic Ang II infusion in uninephrectomized rats significantly increased intrarenal Ang II levels (354 vs 164 fmol/g) and systolic pressure, which were prevented by losartan treatment.
Why the study?
Does losartan prevent the augmentation of intrarenal Angiotensin II and development of hypertension in Angiotensin II-infused uninephrectomized rats?
Population
Male Sprague-Dawley rats, uninephrectomized
Comparison
Angiotensin II infusion via subcutaneous osmotic… vs Vehicle infusion
Design
Preclinical
Follow-up
13 days
Authors
Loading...
Caution against clinical extrapolation from this model; leaves open receptor dependence of intrarenal Ang II enhancement.
Does losartan prevent the augmentation of intrarenal Angiotensin II and development of hypertension in Angiotensin II-infused uninephrectomized rats?
Absolute Event Rate: 354% vs 164%
Zou et al. (1996) studied Hypertension. Angiotensin II infusion vs. Vehicle was evaluated on Intrarenal Angiotensin II levels. Chronic Ang II infusion in uninephrectomized rats significantly increased intrarenal Ang II levels (354 vs 164 fmol/g) and systolic pressure, which were prevented by losartan treatment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: