Why the study?
Does AT1 receptor blockade with losartan reduce the intrarenal uptake of circulating ANG II in rats with ANG II-induced hypertension?
Population
22 uninephrectomized male Sprague-Dawley rats
Comparison
Val5-ANG II infusion plus losartan treatment vs Val5-ANG II infusion alone (n=8) and control (n=6)
Design
Preclinical
Follow-up
12 days
Authors
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Should not change hypertension practice; hypothesis-generating for AT1-dependent intrarenal ANG II uptake in humans.
Does AT1 receptor blockade with losartan reduce the intrarenal uptake of circulating ANG II in rats with ANG II-induced hypertension?
AT1 receptor blockade markedly reduces the intrarenal uptake of circulating ANG II in ANG II-induced hypertension, demonstrating that accumulation of infused ANG II in the kidney requires AT1 receptor activation.
Long Zou (1998) studied this question.
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