Why the study?
Does chronic ANG II infusion stimulate endogenous intrarenal ANG II formation in rats?
Population
28 male Sprague-Dawley rats (240 to 270 g body weight)
Comparison
Val5-ANG II or Ile5-ANG II infused at 80 ng/min… vs Sham operated rats
Design
Preclinical
Follow-up
13 days
Authors
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No immediate clinical implications; extends experimental models of intrarenal ANG II regulation in hypertension.
Does chronic ANG II infusion stimulate endogenous intrarenal ANG II formation in rats?
Chronic ANG II infusion in rats leads to substantial stimulation of endogenous intrarenal ANG II formation, which contributes to the overall augmentation of intrarenal ANG II levels.
Shao et al. (2009) studied this question.
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