Population
20 uninephrectomized male Sprague-Dawley rats
Comparison
Infusion of [Ile5]Ang II or [Val5]Ang II at 40… vs Control group
Design
Preclinical
Follow-up
12 days
Authors
Loading...
No immediate clinical implications for hypertension; animal data leaves open relevance of circulating Ang II uptake to human disease.
Circulating Angiotensin II is taken up and accumulates in the kidney, protecting it from degradation and contributing to elevated intrarenal Ang II levels in hypertension models.
Zou et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: