Why the study?
Does candesartan prevent the accumulation of Ang II in renal cortical endosomes during Ang II-induced hypertension in rats?
Population
Rats (n=32 total: 12 controls, 12 Ang II-infused, 8 candesartan-treated)
Comparison
Angiotensin II infusion with or without… vs Control rats
Design
Preclinical
Follow-up
13 days
Authors
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Supports AT1-mediated endosomal Ang II accumulation in rat hypertension model; leaves open human relevance and therapeutic implications.
Does candesartan prevent the accumulation of Ang II in renal cortical endosomes during Ang II-induced hypertension in rats?
Candesartan prevents the substantial intracellular accumulation of angiotensin peptides in renal cortical endosomes during Ang II-dependent hypertension, indicating an AT1 receptor-mediated process.
Zhuo et al. (2002) studied this question.
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