Population
Animal models of angiotensin II dependent hypertension (including 2-kidney-1-clip Goldblatt rats, ANG II…
Design
Review
Authors
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Explains resistant hypertension despite renin depletion; leaves open AT1 internalization as a therapeutic target pending trials.
This review highlights that intrarenal ANG II levels can remain elevated despite renin depletion due to AT1 receptor-mediated internalization, explaining the maintenance of ANG II-dependent hypertension.
Navar et al. (2000) studied this question.
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