Key result
Intrarenal angiotensin II plays a powerful role in the pathogenesis of hypertension, with urinary angiotensinogen excretion rates potentially serving as an index of angiotensin II-dependent hypertension.
Population
Preclinical models (Ang II-infused rats) and general discussion of Ang II-dependent hypertension
Design
Review
Authors
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Intrarenal Ang II compartmentalization may guide future local RAS modulation in hypertension; leaves open clinical translation pending targeted trials.
Intrarenal Ang II plays a powerful role in the pathogenesis of hypertension, and urinary angiotensinogen may serve as a biomarker for Ang II-dependent hypertension.
Navar et al. (2002) conducted a review in Hypertension. Intrarenal Angiotensin II was evaluated. Intrarenal angiotensin II plays a powerful role in the pathogenesis of hypertension, with urinary angiotensinogen excretion rates potentially serving as an index of angiotensin II-dependent hypertension.
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