Key result
The intratubular renin-angiotensin system exhibits robust independent regulation, with proximal intratubular concentrations of Ang I and II significantly exceeding their corresponding plasma levels.
Design
Review
Authors
Loading...
Intratubular RAS may represent a distinct therapeutic axis; leaves open whether local inhibition improves outcomes beyond systemic blockade.
The review highlights the physiological importance of the intratubular renin-angiotensin system, characterized by high local concentrations of Ang II and abundant luminal AT1 receptors.
Navar et al. (2011) conducted a review in Hypertension. Intratubular Renin-Angiotensin System was evaluated. The intratubular renin-angiotensin system exhibits robust independent regulation, with proximal intratubular concentrations of Ang I and II significantly exceeding their corresponding plasma levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: