Why the study?
Does AT1 receptor blockade with olmesartan prevent the augmentation of distal nephron renin in ANG II-infused hypertensive rats?
Population
Male Sprague-Dawley rats (200-220 g), n=24
Comparison
Angiotensin II infusion plus AT1 receptor… vs Sham operated rats and rats with ANG II infusion…
Design
Preclinical
Follow-up
13 days
Authors
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AT1 blockade attenuates medullary renin in ANG II rats; confirms receptor mediation but leaves open human translation.
Does AT1 receptor blockade with olmesartan prevent the augmentation of distal nephron renin in ANG II-infused hypertensive rats?
AT1 receptor blockade with olmesartan prevents the augmentation of distal nephron renin in ANG II-dependent hypertensive rats, demonstrating that this process is AT1 receptor-mediated.
Prieto‐Carrasquero et al. (2005) studied this question.
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