Key result
Chronic angiotensin II infusion for 6 weeks increased systolic blood pressure to 185 ± 4 mmHg compared with 108 ± 2 mmHg in controls, inducing renal injury that was attenuated by losartan.
Absolute Event Rate: 185% vs 108%
Extended 6-week angiotensin II infusion in rats impairs renal autoregulatory capability and induces outward preglomerular remodeling and glomerular injury, which are attenuated by AT1 receptor antagonism with losartan.
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Hypothesis-generating for AT1 blockade in angiotensin-mediated renal injury; leaves open translation to human hypertensive nephropathy.
Casare et al. (2016) studied Angiotensin II-induced hypertension and renal injury. Angiotensin II infusion with or without losartan vs. Sham surgery (control) was evaluated on Systolic blood pressure. Chronic angiotensin II infusion for 6 weeks increased systolic blood pressure to 185 ± 4 mmHg compared with 108 ± 2 mmHg in controls, inducing renal injury that was attenuated by losartan.
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