Why the study?
Does losartan or ramipril prevent renal and vascular injury induced by exogenous Angiotensin II in rats?
Does losartan or ramipril prevent renal and vascular injury induced by exogenous Angiotensin II in rats?
Renal and vascular injury induced by exogenous Angiotensin II is mediated by the AT1 receptor and can be prevented by losartan, but not by ACE inhibition.
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Caution against clinical extrapolation from this rat model; leaves open AT1-specific mechanisms in human Ang II injury.
Lombardi et al. (2001) studied this question.
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