Why the study?
Does candesartan cilexetil prevent cardiovascular and renal damage in hypertensive and vascular injury rat models?
Population
Stroke-prone spontaneously hypertensive rats, rats with balloon-injured carotid arteries, and…
Design
Preclinical
Follow-up
10 weeks
Authors
Loading...
Preclinical data extend AT1 antagonism to vascular and renal injury models; leaves open human translation in hypertension.
Does candesartan cilexetil prevent cardiovascular and renal damage in hypertensive and vascular injury rat models?
AT1-receptor antagonists inhibit growth-related and extracellular matrix gene expression, contributing to protective effects against cardiovascular and renal damage in experimental models.
Kim et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: