Why the study?
Does losartan prevent angiotensin II-induced early histological changes in the heart, liver, and kidneys in rats?
Population
Wistar rats
Comparison
Losartan added to continuous angiotensin II… vs Control and continuous angiotensin II infusion…
Design
Preclinical
Follow-up
72 hours
Authors
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Losartan’s partial protection against Ang II vascular injury in rats should not change practice; leaves open organ-specific mechanisms for human study.
Does losartan prevent angiotensin II-induced early histological changes in the heart, liver, and kidneys in rats?
Angiotensin II induces systemic vascular damage in multiple organs that is only partially prevented by losartan, suggesting organ-specific mechanisms of damage and protection.
Vailati et al. (2010) studied this question.
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