Key result
Angiotensin II decreased pulmonary ACE activity and mRNA levels, an effect not modified by Losartan, indicating tissue-specific regulation likely involving non-AT1 receptors.
Why the study?
Does Angiotensin II and Losartan regulate tissue-specific ACE gene expression and activity in normal rats?
Does Angiotensin II and Losartan regulate tissue-specific ACE gene expression and activity in normal rats?
Angiotensin II regulates gene expression and activity of ACE in a tissue-specific manner in rats, likely involving non-AT1 receptor subtypes.
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Hypothesis-generating for non-AT1 pulmonary ACE regulation in rats; does not support changes in clinical renin-angiotensin blockade.
Metsaurinne et al. (1996) studied Normal rats (n=40). Angiotensin II and Losartan vs. 0.9% NaCl and tap water was evaluated on ACE activity and mRNA levels from pulmonary, cardiac, and renal tissue. Angiotensin II decreased pulmonary ACE activity and mRNA levels, an effect not modified by Losartan, indicating tissue-specific regulation likely involving non-AT1 receptors.
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