Key result
Chronic treatment with enalapril or losartan in normal rats reduced cardiac fibrosis (enalapril 2.1%, losartan 2.2% vs control 3.5%; P<0.05) and induced protective cardiovascular changes.
Why the study?
Does chronic angiotensin II inhibition with enalapril or losartan alter cardiovascular structure and function in normal rats?
Does chronic angiotensin II inhibition with enalapril or losartan alter cardiovascular structure and function in normal rats?
p-value: p=<.05
Chronic renin-angiotensin system inhibition induces protective structural and functional changes in the heart and aorta of normal rats, largely mediated through angiotensin II type 1 receptors.
Authors
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No immediate clinical implications for normotensives; extends preclinical evidence of RAS inhibition effects in healthy models.
Bosc et al. (2000) studied Normal rats (n=48). Enalapril or losartan vs. Control was evaluated on Structure and function of the heart and arteries (p=<.05). Chronic treatment with enalapril or losartan in normal rats reduced cardiac fibrosis (enalapril 2.1%, losartan 2.2% vs control 3.5%; P<0.05) and induced protective cardiovascular changes.
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