Effects of Losartan and Enalapril on Small Artery Structure in Hypertensive Rats

Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats, treated from ages 4 to 12 weeks.

Enalapril (low-dose 1 mg/kg/d or high-dose 25 mg/kg/d) or losartan (low-dose 0.5 mg/kg/d or high-dose 15 mg/kg/d) administered from ages 4 to 12 weeks.

Untreated SHR and untreated WKY rats.

Systolic blood pressure and cardiovascular structural parameters (relative left ventricular mass, media/lumen ratio, cell volume, number of cells per segment length, and number of cell layers of mesenteric small arteries) evaluated at 13 weeks of age.surrogate