Why the study?
Does enalapril, losartan, or their combination improve systemic and coronary hemodynamics in spontaneously hypertensive rats?
Population
23-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) normotensive control rats
Comparison
Enalapril, losartan, or their combination for 12… vs Tap water and normotensive WKY controls
Design
Preclinical
Follow-up
12 weeks
Authors
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Does not support clinical use of dual ACEI/ARB blockade; leaves open translation of synergistic LV and coronary effects to humans.
Does enalapril, losartan, or their combination improve systemic and coronary hemodynamics in spontaneously hypertensive rats?
The combination of an ACE inhibitor and an AT1 receptor antagonist is more effective than either agent alone in reducing blood pressure and LV mass and improving coronary hemodynamics in a hypertensive rat model.
Núñez et al. (1997) studied this question.
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