Why the study?
Does losartan reduce cardiovascular mass and improve hemodynamics in spontaneously hypertensive rats?
Population
Conscious spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Losartan vs Untreated SHR and WKY rats
Design
Preclinical
Follow-up
3 weeks
Authors
Loading...
Extends evidence for load-independent LV mass effects in hypertension models; leaves open translation to human therapy.
Does losartan reduce cardiovascular mass and improve hemodynamics in spontaneously hypertensive rats?
Losartan administration reduces left ventricular mass and improves coronary flow reserve in spontaneously hypertensive rats, effects that appear partially independent of afterload reduction.
Kaneko et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: