Key result
Both enalapril and losartan increased medullary blood flow by 30% at renal arterial pressures of 125 mmHg and over in spontaneously hypertensive rats.
Why the study?
Does short-term enalapril or losartan alter medullary hemodynamics in spontaneously hypertensive rats?
Population
Male 12-13-week-old spontaneously hypertensive rats (SHR), n=58
Comparison
Enalapril or losartan for 3 days, with or… vs Untreated spontaneously hypertensive rats
Design
Preclinical
Follow-up
3 days
Authors
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Should not change clinical practice; leaves open medullary flow modulation by RAS inhibitors in hypertensive models.
Does short-term enalapril or losartan alter medullary hemodynamics in spontaneously hypertensive rats?
Both enalapril and losartan increase medullary blood flow in spontaneously hypertensive rats, suggesting endogenous angiotensin II influences medullary circulation, while kinins mediate enalapril's effects on renal interstitial hydrostatic pressure.
Dukacz et al. (1999) studied Hypertension (Spontaneously hypertensive rats) (n=58). Enalapril or losartan vs. Untreated was evaluated on Medullary blood flow (MBF) and renal interstitial hydrostatic pressure (RIHP). Both enalapril and losartan increased medullary blood flow by 30% at renal arterial pressures of 125 mmHg and over in spontaneously hypertensive rats.
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