What question did this study set out to answer?

This research aims to determine how long-term enalapril treatment affects pressure-natriuresis in spontaneously hypertensive rats.

July 1, 1997AJP Renal Physiology

The persistent effect of long-term enalapril on pressure natriuresis in spontaneously hypertensive rats

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Why the study?

Does long-term enalapril treatment shift the pressure-natriuresis relation to maintain a persistent antihypertensive effect in spontaneously hypertensive rats?

Key Points

This research aims to determine how long-term enalapril treatment affects pressure-natriuresis in spontaneously hypertensive rats.
Male spontaneously hypertensive rats (SHR) aged 18 weeks were anesthetized for renal function assessments.
Enalapril was administered at 25 mg.kg-1.day-1 starting from 4 to 14 weeks of age, with additional short-term treatment before tests.
Four groups were tested based on treatment duration: 10-week, 10-week + 3-day, 3-day, and untreated.
Pressure-natriuresis curves for the long-term treatment group were shifted leftward by approximately 25 mmHg compared to untreated SHR.
The combined group of 10-wk treatment and additional 3-day treatment showed a further leftward shift of 30 mmHg in pressure-natriuresis.
Hemodynamic changes were observed with enalapril treatment that improved sodium excretion at lower renal artery pressures.

Structured PICO

Does long-term enalapril treatment shift the pressure-natriuresis relation to maintain a persistent antihypertensive effect in spontaneously hypertensive rats?

Population

35 male, anesthetized spontaneously hypertensive rats (SHR) at 18 weeks of age

Intervention

Enalapril (25 mg/kg/day in drinking water) administered from 4 to 14 weeks of age (10-week treatment), 10-week + 3-day treatment, or 3-day treatment

Comparator

Untreated spontaneously hypertensive rats

Outcome

Pressure-natriuresis relation and mean arterial pressuresurrogate

Long-term enalapril treatment in spontaneously hypertensive rats causes a persistent reduction in arterial pressure by shifting the pressure-natriuresis relationship leftward.

Discussion

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Implication

May reset pressure-natriuresis persistently in SHR; hypothesis-generating, requires human validation before clinical consideration.

Cite This Study

Dukacz et al. (1997) studied this question.

synapsesocial.com/papers/6a208be415e15183b6b58000 https://doi.org/10.1152/ajprenal.1997.273.1.f104

Topics

Hypertension management

View Full Paper

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The persistent effect of long-term enalapril on pressure natriuresis in spontaneously hypertensive rats

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

The persistent effect of long-term enalapril on pressure natriuresis in spontaneously hypertensive rats

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider