Why the study?
Does enalapril alter renal sodium transporter abundance and distribution in spontaneously hypertensive rats?
Population
9-week-old spontaneously hypertensive rats (SHR)
Comparison
Enalapril 30 mg/kg/day for 4 weeks vs Untreated SHR, normotensive rat strains, and SHR…
Design
Preclinical
Follow-up
4 weeks
Authors
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ACEI may redistribute renal Na+ transporters in SHR independent of BP; leaves open mechanistic relevance to human hypertension therapy.
Does enalapril alter renal sodium transporter abundance and distribution in spontaneously hypertensive rats?
Chronic ACE inhibition with enalapril in spontaneously hypertensive rats lowers blood pressure and provokes the retraction and reduced abundance of renal sodium transporters, an effect not seen with other antihypertensives.
Yang et al. (2007) studied this question.
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