Key result
Both 10-week and 3-day enalapril treatment independently increased the slope of the renal arterial pressure versus medullary blood flow relationship at RAP > 100 mmHg compared to untreated rats.
Population
Male spontaneously hypertensive rats (SHR), n=34
Comparison
Enalapril given for 3 days, 10 weeks, or 10… vs Untreated spontaneously hypertensive rats
Design
Preclinical
Follow-up
Up to 14 weeks of age plus 4 weeks withdrawal
Authors
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Enalapril alters renal medullary hemodynamics in hypertensive rats; leaves open translation to human pressure-natriuresis resetting.
Short- and long-term enalapril treatment alters renal medullary hemodynamics in spontaneously hypertensive rats, which may contribute to resetting the pressure-natriuresis relationship.
Dukacz et al. (1999) studied Hypertension (n=34). Enalapril vs. Untreated was evaluated on Slope of the renal arterial pressure (RAP) versus medullary blood flow (MBF) relationship at RAP > 100 mmHg. Both 10-week and 3-day enalapril treatment independently increased the slope of the renal arterial pressure versus medullary blood flow relationship at RAP > 100 mmHg compared to untreated rats.
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