Key result
Long-term treatment with enalapril in spontaneously hypertensive rats decreased the sensitivity of renal medullary blood flow to angiotensin II and improved endothelium-dependent vascular relaxation.
Why the study?
Does long-term enalapril treatment correct the abnormal renal medullary response to angiotensin II in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats (assessed at 18-19 weeks of age)
Comparison
Enalapril 25 mg/kg/day administered from 4 to 14… vs Untreated control SHR and WKY rats
Design
Preclinical
Follow-up
Treatment for 10 weeks, assessed at 18-19 weeks
Authors
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May improve medullary flow regulation in hypertensive models; hypothesis-generating for ACE inhibitor mechanisms, no clinical translation yet.
Does long-term enalapril treatment correct the abnormal renal medullary response to angiotensin II in spontaneously hypertensive rats?
Long-term enalapril treatment in spontaneously hypertensive rats corrects abnormal renal medullary blood flow sensitivity to angiotensin II, likely by improving nitric oxide-mediated counterregulation.
Dukacz et al. (2001) studied Spontaneously hypertensive rats (SHR). Enalapril vs. Control SHR / WKY rats was evaluated on Renal medullary blood flow (MBF) response to angiotensin II. Long-term treatment with enalapril in spontaneously hypertensive rats decreased the sensitivity of renal medullary blood flow to angiotensin II and improved endothelium-dependent vascular relaxation.
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