Key result
Enalapril treatment produced a large decrease in subfornical organ ANG II receptors in spontaneously hypertensive rats and inhibited plasma ACE activity by 85%.
Why the study?
Does enalapril alter brain angiotensin II receptors in spontaneously hypertensive rats?
Does enalapril alter brain angiotensin II receptors in spontaneously hypertensive rats?
Enalapril selectively decreases subfornical organ ANG II receptors in spontaneously hypertensive rats, suggesting a central mechanism of action for ACE inhibitors.
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Suggests central ACE inhibitor effects in hypertensive rat models; leaves open human translation and clinical relevance.
Nazarali et al. (1989) studied Hypertension. Enalapril vs. Untreated rats was evaluated on Brain angiotensin II (ANG II) receptors. Enalapril treatment produced a large decrease in subfornical organ ANG II receptors in spontaneously hypertensive rats and inhibited plasma ACE activity by 85%.
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