March 1, 1995Hypertension

Enalapril Does Not Prevent Renal Arterial Hypertrophy in Spontaneously Hypertensive Rats

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Why the study?

Does enalapril prevent renal arterial hypertrophy in spontaneously hypertensive rats?

Structured PICO

Does enalapril prevent renal arterial hypertrophy in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR, n=7), SHR treated with enalapril (SHR-E, n=7), and Wistar-Kyoto rats (WKY, n=7)

Intervention

Enalapril 25 to 30 mg/kg per day administered from 4 to 10 weeks of age

Comparator

Untreated spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY)

Outcome

Wall and lumen dimensions of the interlobular (cortical radial) and arcuate arteries in the kidneys (volume density of artery wall, wall-to-lumen ratio, and wall thickness) at 10 weeks of agesurrogate

Enalapril lowers blood pressure but does not prevent renal arterial hypertrophy in spontaneously hypertensive rats.

Authors

MKMichelle M. KettMonash University DADaine AlcornThe University of Melbourne JBJohn F. BertramAustralian Regenerative Medicine Institute

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Enalapril does not regress renal arterial hypertrophy in SHR despite BP reduction; leaves open pressure-independent mechanisms in hypertensive vascular remodeling.

Cite This Study

Kett et al. (1995) studied this question.

synapsesocial.com/papers/6a865ca8f5121d64a72ed3d8 https://doi.org/10.1161/01.hyp.25.3.335

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Implication

Enalapril does not regress renal arterial hypertrophy in SHR despite BP reduction; leaves open pressure-independent mechanisms in hypertensive vascular remodeling.

Enalapril Does Not Prevent Renal Arterial Hypertrophy in Spontaneously Hypertensive Rats

Structured PICO

Discussion

Implication

Cite This Study

Enalapril Does Not Prevent Renal Arterial Hypertrophy in Spontaneously Hypertensive Rats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider