Key result
Systemic inhibition of angiotensin converting enzyme with enalapril produced a large decrease in ANG II receptors localized exclusively in the subfornical organ of spontaneously hypertensive rats.
Why the study?
Does enalapril alter Angiotensin II receptor density in the brain of spontaneously hypertensive rats?
Does enalapril alter Angiotensin II receptor density in the brain of spontaneously hypertensive rats?
Enalapril selectively decreases Angiotensin II receptors in the subfornical organ of spontaneously hypertensive rats, providing a potential central mechanism for its therapeutic efficacy.
Suggests central mechanism for enalapril in rat hypertension; leaves open human relevance and clinical translation.
Angiotensin II (ANG II) receptor density was higher in many brain regions of untreated spontaneously hypertensive rats (SHR) compared to untreated Wistar-Kyoto (WKY) animals. Systemic inhibition of angiotensin converting enzyme with enalapril (25 mg/kg, per os for 14 days) produces a large decrease in ANG II receptors localized exclusively in the subfornical organ (SFO) of the SHR, and no alterations in ANG II receptors in the normotensive WKY rats. Selective decrease of ANG II receptors in the SFO of the genetically hypertensive rats with enalapril may be related to its therapeutic efficacy.
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Nazarali et al. (1990) studied Hypertension. Enalapril vs. Untreated rats / WKY rats was evaluated on Angiotensin II (ANG II) receptor density in the subfornical organ (SFO). Systemic inhibition of angiotensin converting enzyme with enalapril produced a large decrease in ANG II receptors localized exclusively in the subfornical organ of spontaneously hypertensive rats.
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