Why the study?
Does transplantation of enalapril-treated kidneys reduce mean arterial pressure in spontaneously hypertensive rats?
Does transplantation of enalapril-treated kidneys reduce mean arterial pressure in spontaneously hypertensive rats?
Pharmacotherapy with enalapril induces persistent, kidney-specific changes that determine arterial pressure, highlighting the kidney as a key therapeutic target in hypertension.
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Hypothesis-generating for kidney-specific ACEI effects in rat hypertension; leaves open human translation and should not alter clinical practice.
Smallegange et al. (2003) studied this question.
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