Why the study?
Does transplanting kidneys from rats treated with brief antihypertensive therapy reduce arterial pressure in untreated spontaneously hypertensive rats?
Does transplanting kidneys from rats treated with brief antihypertensive therapy reduce arterial pressure in untreated spontaneously hypertensive rats?
Brief antihypertensive therapy induces persistent, kidney-specific changes in vascular structure that can transfer blood pressure lowering effects via transplantation in a rat model.
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Brief antihypertensive effects may persist via renal mechanisms in rats; leaves open human translation.
Smallegange et al. (2004) studied this question.
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