What question did this study set out to answer?

To determine whether essential hypertension and associated vascular damage resolve following kidney transplantation from normotensive donors.

October 27, 1983New England Journal of Medicine

Remission of Essential Hypertension after Renal Transplantation

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Why the study?

Does kidney transplantation from normotensive donors normalize blood pressure in patients with end-stage renal disease due to essential hypertension?

Population

12 subjects total: 6 black patients with essential hypertension leading to nephrosclerosis and kidney…

Comparison

Kidney transplantation from normotensive donors vs Normal control subjects matched for age, sex…

Design

Case-control

Follow-up

average 4.5 years

Authors

JCJohn J. CurtisUniversity of Alabama at Birmingham RLRobert LukeAustralian Hearing HDHarriet P. DustanGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Post-transplant normotension matches controls; supports renal etiology hypothesis but leaves open generalizability beyond this small series.

Key Points

To determine whether essential hypertension and associated vascular damage resolve following kidney transplantation from normotensive donors.
Followed 6 Black patients with end-stage renal failure from essential hypertension who received kidney transplants from normotensive donors for an average of 4.5 years.
Admitted the 6 transplant recipients alongside 6 age-, sex-, and race-matched normal control subjects for an 11-day clinical observation evaluating blood pressure responses to salt deprivation and salt loading.
All 6 transplant recipients achieved sustained normotension and showed reversal of hypertensive damage in cardiac and retinal vessels after 4.5 years of follow-up.
Mean arterial pressure was 92 ± 1.9 mm Hg in former hypertension patients versus 94 ± 3.9 mm Hg in matched controls (P not significant), with similar physiological responses to dietary salt loading and deprivation.

Structured PICO

Does kidney transplantation from normotensive donors normalize blood pressure in patients with end-stage renal disease due to essential hypertension?

Population

12 subjects total: 6 black patients with essential hypertension leading to nephrosclerosis and kidney failure who received kidney transplants from normotensive donors, and 6 normal control subjects matched for age, sex, and race.

Intervention

Kidney transplantation from normotensive donors

Comparator

Normal control subjects matched for age, sex, and race

Outcome

Mean arterial pressure and blood pressure response to salt deprivation and salt loadingsurrogate

Kidney transplantation from normotensive donors normalizes blood pressure in patients with essential hypertension, suggesting a primary renal etiology for the disease.

Cite This Study

Curtis et al. (1983) studied this question.

synapsesocial.com/papers/6a6f92cc84cc45bb7bdfa3da https://doi.org/10.1056/nejm198310273091702

Topics

Hypertension management

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Implication

Post-transplant normotension matches controls; supports renal etiology hypothesis but leaves open generalizability beyond this small series.

Remission of Essential Hypertension after Renal Transplantation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Remission of Essential Hypertension after Renal Transplantation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider