Why the study?
Does transplantation of kidneys from stroke-prone spontaneously hypertensive rats increase blood pressure in normotensive recipients?
Population
14 bilaterally nephrectomized age-matched male F1 hybrids bred from stroke-prone spontaneously hypertensive…
Comparison
Transplantation of kidneys from adult male… vs Transplantation of kidneys from adult male…
Design
Preclinical
Follow-up
8 weeks
Authors
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Does not inform clinical hypertension management; leaves open whether renal mechanisms drive human essential hypertension.
Does transplantation of kidneys from stroke-prone spontaneously hypertensive rats increase blood pressure in normotensive recipients?
Transplantation of kidneys from hypertensive rats to normotensive rats causes hypertension, demonstrating a major role for the kidney in the pathogenesis of hypertension in this model.
Rettig et al. (1989) studied this question.
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