Why the study?
Does enalapril improve survival and prevent stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats?
Population
33 male stroke-prone spontaneously hypertensive rats fed a Japanese rat chow plus a 1% NaCl drinking…
Comparison
Enalapril 15 mg/kg/day administered in the… vs Untreated control SHRSP
Design
Preclinical
Follow-up
up to 36 weeks
Authors
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Animal findings should not change hypertension practice; hypothesis-generating for BP-independent ACE inhibitor effects in stroke-prone models.
Does enalapril improve survival and prevent stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats?
In a rat model of severe hypertension, ACE inhibition with enalapril prevented stroke and kidney dysfunction and improved survival independent of blood pressure lowering.
Stier et al. (1989) studied this question.
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