Why the study?
Does oral Captopril prevent stroke and renal pathology in salt-loaded stroke-prone spontaneously hypertensive rats?
Population
14 stroke-prone spontaneously hypertensive rats fed Stroke-Prone Rodent Diet and 1% NaCl drinking solution
Comparison
Oral Captopril beginning at 8.4 weeks of age vs Untreated SHRSP fed the same diet and salt…
Design
Preclinical
Follow-up
up to 26 weeks of age
Authors
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Cautions against clinical use from animal data alone; extends preclinical evidence for ACE inhibition in hypertensive stroke models.
Does oral Captopril prevent stroke and renal pathology in salt-loaded stroke-prone spontaneously hypertensive rats?
Captopril protects against stroke and vascular lesions in salt-loaded stroke-prone spontaneously hypertensive rats independently of blood pressure reduction.
Stier et al. (1991) studied this question.
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