What does this research mean for the field?

Captopril lowers blood pressure and prevents the development of hypertension in two-kidney Goldblatt and spontaneously hypertensive rats, but is ineffective in DOCA-salt hypertension, reflecting differing renin dependencies among these models. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1980Folia Endocrinologica JaponicaOpen Access

Comparison of Blood Pressure Responses to Captopril, an Orally Active Converting Enzyme Inhibitor, in Rats with Various Forms of Experimental Hypertension

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Why the study?

Does captopril reduce blood pressure in normal rats and rats with various forms of experimental hypertension?

Structured PICO

Does captopril reduce blood pressure in normal rats and rats with various forms of experimental hypertension?

Population

Normal rats and rats with two-kidney Goldblatt hypertension (2KGH), spontaneous hypertension (SH), and DOCA-salt hypertension (DSH).

Intervention

Captopril dissolved in drinking water at a concentration of 0.5 mg/ml (mean consumption ranging from 67 to >200 mg/kg/day depending on the model).

Comparator

Untreated control rats (for normal, prevention studies, and DSH models) or baseline control period (for chronic 2KGH and SH models).

Outcome

Blood pressure measured using a plethysmographic tail method without anesthesia.surrogate

Captopril effectively lowers blood pressure in renin-dependent and spontaneous hypertension models but not in DOCA-salt hypertension, without inducing diuresis or natriuresis.

Discussion

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Implication

Supports model-specific BP responses to captopril in rats; leaves open translation to human hypertension subtypes.

Cite This Study

Mikami et al. (1980) studied this question.

synapsesocial.com/papers/6a1cc8d5732133fe9885e27a https://doi.org/10.1507/endocrine1927.56.2_180

Topics

Hypertension management

View Full Paper

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Comparison of Blood Pressure Responses to Captopril, an Orally Active Converting Enzyme Inhibitor, in Rats with Various Forms of Experimental Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Topics

Comparison of Blood Pressure Responses to Captopril, an Orally Active Converting Enzyme Inhibitor, in Rats with Various Forms of Experimental Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider