Why the study?
Does lifetime captopril treatment alter angiotensin II receptors and physiological responses in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR), including pregnant and nursing dams and their offspring.
Comparison
Oral captopril for 21 weeks. vs Age-matched control spontaneously hypertensive…
Design
Preclinical
Follow-up
21 weeks
Authors
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Hypothesis-generating for divergent central-peripheral RAS adaptations with chronic ACE inhibition; leaves open human translation.
Does lifetime captopril treatment alter angiotensin II receptors and physiological responses in spontaneously hypertensive rats?
Lifetime captopril treatment in spontaneously hypertensive rats lowers blood pressure while inducing divergent adaptations in the central and peripheral renin-angiotensin systems.
Wilson et al. (1988) studied this question.
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