Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1986Clinical and Experimental Hypertension

Alterations in Renal Vascular Reactivity Induced by Chronic Central Administration of Captopril in the Spontaneously Hypertensive Rat

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does chronic central administration of captopril reduce vascular reactivity to vasoconstrictors in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats

Comparison

Captopril infused via osmotic mini pumps… vs ICV vehicle or intravenous (IV) captopril

Design

Preclinical

Follow-up

4 weeks

Authors

KBKathleen H. BerecekUniversity of IowaDSDavid ShierUniversity of Toledo Medical Center

Discussion

Loading...

Member takes

Implication

Central captopril may attenuate hypertension in SHR models; hypothesis-generating for central RAS targeting, human trials required.

Structured PICO

Does chronic central administration of captopril reduce vascular reactivity to vasoconstrictors in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
I
Intervention
Captopril (1.25 micrograms/hr) infused via osmotic mini pumps intracerebroventricularly (ICV) for 4 weeks
C
Comparator
ICV vehicle or intravenous (IV) captopril
O
Outcome
Vascular reactivity to norepinephrine, angiotensin and vasopressin in isolated perfused kidneyssurrogate

Chronic central administration of captopril attenuates the development of hypertension in spontaneously hypertensive rats by decreasing vascular reactivity to vasoconstrictors.

Cite This Study

Berecek et al. (1986) studied this question.

synapsesocial.com/papers/6a735a75668da3c6682c29bbhttps://doi.org/10.3109/10641968609045476

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Attenuation of the development of spontaneous hypertension in rats by chronic central administration of captopril.1983 · 59 citations
  2. 2Blood pressure responses of conscious normotensive and spontaneously hypertensive rats to intracerebroventricular and peripheral administration of captopril.1980 · 90 citations
  3. 3Pre- and postjunctional inhibition of vascular sympathetic function by captopril in SHR. Implication of vascular angiotensin II in hypertension and antihypertensive actions of captopril.1981 · 129 citations
  4. 4Alterations in renal vascular resistance and reactivity in spontaneous hypertension of rats1980 · 77 citations
  5. 5Angiotensin-like immunoreactivity in the brain of the spontaneously hypertensive rat.1982 · 133 citations