Why the study?
Does continuous oral administration of captopril reduce systolic blood pressure in two-kidney Goldblatt hypertensive rats and spontaneously hypertensive rats?
Population
Two-kidney Goldblatt hypertensive (2 KGH) rats and spontaneously hypertensive rats (SHR)
Comparison
Continuous oral administration of captopril vs Untreated 2 KGH rats and SHR
Design
Preclinical
Follow-up
up to 28 days
Authors
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Cautions against clinical extrapolation from rodent data; leaves open mechanistic studies of ACE inhibition in hypertension models.
Does continuous oral administration of captopril reduce systolic blood pressure in two-kidney Goldblatt hypertensive rats and spontaneously hypertensive rats?
Captopril demonstrates antihypertensive effects in both two-kidney Goldblatt hypertensive rats and spontaneously hypertensive rats, despite increases in juxtaglomerular index and cell counts.
Yamakoshi et al. (1991) studied this question.
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