Why the study?
Does captopril reduce arterial blood pressure in acute and chronic two-kidney Goldblatt hypertensive dogs?
Population
Acute and chronic two-kidney Goldblatt hypertensive dogs, and normotensive dogs
Comparison
Captopril oral administration of 10, 20 and 40… vs Normotensive dogs
Design
Preclinical
Follow-up
21 days
Authors
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Supports stage-specific captopril responses in renovascular hypertension; leaves open human translation pending clinical studies.
Does captopril reduce arterial blood pressure in acute and chronic two-kidney Goldblatt hypertensive dogs?
Captopril effectively lowers blood pressure in two-kidney Goldblatt hypertensive dogs, with differing mechanisms of blood pressure maintenance suggested between acute and chronic stages.
Ohara et al. (1982) studied this question.
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