Key result
Captopril administration increased plasma renin activity by 2.0, 2.8, and 3.5 fold in dogs with renovascular hypertension, independent of systemic pressure changes.
Why the study?
Does captopril increase plasma renin activity independent of systemic pressure changes in dogs with renovascular hypertension?
Does captopril increase plasma renin activity independent of systemic pressure changes in dogs with renovascular hypertension?
Renovascular hypertension sensitizes the kidney to release renin in response to captopril, an effect that is independent of changes in systemic pressure.
Does not support clinical translation from dogs; leaves open renin modulation by renovascular hypertension in humans.
The increase in plasma renin activity induced by captopril is used in the clinical evaluation of renovascular hypertensive patients. This increase in plasma renin activity could result from either the concomitant fall in systemic pressure or other effects of captopril, such as the removal of an angiotensin II inhibitory effect on renin release, the increased production of bradykinin or prostaglandins, etc. To examine the effect captopril has on plasma renin activity, independent of changes in systemic pressure, captopril (5, 10 and 50 micrograms/kg iv) was administered to conscious dogs before and following the development of 1 clip-2 kidney Goldblatt hypertension. Plasma renin activity, under normal conditions remained unchanged, while during hypertension it increased 2.0, 2.8 and 3.5 fold respectively in response to the three doses of captopril. These results suggest that the development of renovascular hypertension sensitized the kidney to release renin when challenged by captopril and that the effect is independent of changes in systemic pressure.
No takes yet. Share an insight, caveat, or question.
Zachariah et al. (1989) studied Renovascular hypertension. Captopril vs. Normal conditions (before hypertension development) was evaluated on Plasma renin activity. Captopril administration increased plasma renin activity by 2.0, 2.8, and 3.5 fold in dogs with renovascular hypertension, independent of systemic pressure changes.