Key result
Daily captopril therapy for one year caused significant and sustained reductions in systolic blood pressure and improved survival in 2-kidney renal hypertensive rats.
Why the study?
Does captopril reduce systolic blood pressure and improve survival in 2-kidney renal hypertensive rats?
Population
2-kidney renal hypertensive rats (2K-RHR)
Comparison
Captopril 30 mg/kg p.o. daily for one year… vs Water or HCTZ alone
Design
Preclinical
Follow-up
1 year
Authors
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Hypothesis-generating for long-term ACE inhibition in renal hypertension; leaves open translation to human outcomes.
Does captopril reduce systolic blood pressure and improve survival in 2-kidney renal hypertensive rats?
Long-term captopril therapy significantly reduces systolic blood pressure and improves survival in a rat model of renal hypertension, with enhanced effects when combined with a diuretic.
Antonaccio et al. (1979) studied 2-kidney renal hypertension. Captopril vs. Water or HCTZ alone was evaluated on Systolic blood pressure, heart rate, and survival. Daily captopril therapy for one year caused significant and sustained reductions in systolic blood pressure and improved survival in 2-kidney renal hypertensive rats.
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